Unlocking the Mind: What Does a Ketamine Infusion Really Feel Like?

Headshot of Charles Maddix APRN, MSN, PMHNP-BC
Charles Maddix, APRN, MSN, PMHNP-BC
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March 31, 2023

Ketamine is a medication that is used for pain management and anesthesia. However, it has recently been found to be an effective treatment for depression, anxiety, and other mental health disorders. Ketamine infusion therapy is becoming more and more popular as a way to treat these conditions. For someone who has never experienced it, the idea of receiving a Ketamine infusion may seem daunting. In this article, we will explore what a Ketamine infusion feels like, based on personal accounts from those who have undergone the treatment.

Ketamine infusion therapy involves receiving a dose of Ketamine through an IV drip. The amount of Ketamine administered is carefully measured and monitored by medical professionals. During the infusion, patients are typically seated or lying down in a comfortable, quiet room. The infusion can last anywhere from 45 minutes to a few hours, depending on the dosage and the patient's individual needs.

The effects of Ketamine infusion therapy can vary from person to person. Some people report feeling a sense of euphoria or a "floating" sensation. Others describe feeling a dissociative state, where they feel disconnected from their body or surroundings. Many people also report feeling a sense of calm and relaxation.

One person who underwent Ketamine infusion therapy for depression and anxiety described the experience as follows: "I felt like I was floating on a cloud. My body felt weightless, and I was completely relaxed. I didn't feel anxious or depressed at all. It was like all of my worries just melted away."

Another individual who underwent Ketamine infusion therapy for chronic pain described feeling a "buzzing" sensation throughout their body. They reported feeling less pain and more energy after the treatment.

It's important to note that Ketamine infusion therapy is a medical treatment and should only be administered by qualified medical professionals. It's also important to follow the treatment plan prescribed by your healthcare provider and to discuss any concerns or questions you may have about the treatment.

In conclusion, Ketamine infusion therapy can feel different for everyone who undergoes it. Some people may feel a sense of euphoria or dissociation, while others may feel more relaxed and calm. If you are considering Ketamine infusion therapy, it's important to talk to your healthcare provider and to carefully consider the risks and benefits of the treatment.


American Psychiatric Association. (2017). Ketamine for Treatment-Resistant Depression: The First Decade of Progress. Retrieved from https://www.psychiatry.org/File%20Library/Psychiatrists/Practice/Clinical%20Practice%20Guidelines/APA-Detailed-Ketamine-Depression-Guideline.pdf

Owen, A. (2019, September 26). What Does a Ketamine Infusion Feel Like? Retrieved from https://www.healthline.com/health/what-does-a-ketamine-infusion-feel-like

Schoenfeld, H. (2019, August 26). What It's Like to Get a Ketamine Infusion for Depression. Retrieved from https://www.self.com/story/ketamine-infusion-depression

Charles Maddix is the Owner & CEO of The Practice.  A private practice focused on the well-being of the individual as a whole, mind and body.

Among the unique modalities offered by The Practice are:

Ketamine Infusion therapy– Ketamine infusion therapy involves the administration of a series of infusions for the management of psychiatric disorders like major depressive disorder, post-traumatic stress disorder, and acute suicidality.  Working very quickly — in many, often within hours — to ease symptoms.

Bioidentical hormone replacement therapy - Bioidentical hormone replacement therapy (BHRT) uses hormones that are chemically identical to the hormones naturally produced in the human body. Derived from plant sources and formulated to match the molecular structure of hormones produced by the body. BHRT is used to treat symptoms of hormonal imbalances, in both men and women.

NeuroStar® TMS – NeuroStar® TMS delivers our advanced and unique form of TMS (transcranial magnetic stimulation), a non-invasive therapy that uses targeted magnetic pulses to stimulate areas of the brain that are underactive in people suffering from depression.

Opioid Replacement Therapy - Opioid replacement therapy (ORT) is an effective treatment for addiction to opioid drugs such as heroin, oxycodone, hydromorphone (Dilaudid), fentanyl and Percocet. The therapy involves taking the opioid agonists buprenorphine (Suboxone). This medication works to prevent withdrawal and reduce cravings for opioid drugs.

Invega Sustena – a once-monthly injection treatment approved by the FDA for bipolar 1 disorder maintenance. This eliminates the need for daily oral medications in appropriate patients.Allergy Immunotherapy -

Allergen immunotherapy, also known as allergy shots, is a long-term treatment that decreases symptoms for many people with allergies often leading to lasting relief of allergy symptoms even after treatment is stopped. This makes it a cost-effective, beneficial treatment approach for many people.

Please call 904.877.1100 if you are interested in any of our services or would like to schedule an appointment.  Visit us at thepractice.co to learn more!