Dealing with the Dark Side of Vyvanse: Male Anger

Headshot of Charles Maddix APRN, MSN, PMHNP-BC
Charles Maddix, APRN, MSN, PMHNP-BC
calendar icon
March 24, 2023

Vyvanse is a prescription medication that is commonly used to treat attention deficit hyperactivity disorder (ADHD) and binge eating disorder. It is a central nervous system (CNS) stimulant that works by increasing the levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine. While Vyvanse can be an effective treatment for many people, it can also cause side effects, including anger in males.

Anger is a common side effect of Vyvanse, especially in males. While it is not clear why males are more susceptible to anger while taking Vyvanse, it is believed to be related to the medication's effects on the brain's dopamine and norepinephrine systems.

Dopamine isa neurotransmitter that plays a role in reward and motivation, while norepinephrine is a neurotransmitter that is involved in the body's stress response. When Vyvanse increases the levels of these neurotransmitters in the brain, it can lead to an increase in irritability, aggression, and anger.

not all people who take Vyvanse will experience anger as a side effect

In addition to its effects on neurotransmitters, Vyvanse can also cause physical symptoms that may contribute to feelings of anger. These can include increased heart rate, sweating, and muscle tension, which can all be signs of stress and can contribute to feelings of irritability and anger.

It is important to note that not all people who take Vyvanse will experience anger as a side effect. Additionally, anger may be a temporary side effect that goes away as the body adjusts to the medication. However, if anger persists or becomes severe, it is important to speak with your provider.

There are several strategies that can help manage anger as a side effect of Vyvanse.These include:

  1. Taking breaks: If you feel yourself becoming angry or irritable,taking a break and stepping away from the situation can help you calm down and regain control.
  2. Practicing relaxation techniques: Activities like deep breathing, yoga, or meditation can help reduce feelings of stress and promote feelings of calm.
  3. Talking to a therapist: A therapist can help you develop strategies for managing anger and other emotional side effects of Vyvanse.
  4. Adjusting the dosage: If the side effects of Vyvanse are severe or persistent, adjusting the dosage may help reduce symptoms.

In summation, while Vyvanse can be an effective treatment for ADHD and binge eating disorder, it can also cause anger as a side effect, particularly in males. If you are experiencing anger or other emotional side effects while taking Vyvanse, it is important to speak with your provider about strategiesf or managing these symptoms. With the right support, it is possible to effectively manage the side effects of Vyvanse and maintain a healthy and happy life.

Charles Maddix is the Owner & CEO of The Practice.  A private practice focused on the well-being of the individual as a whole, mind and body.

Among the unique modalities offered by The Practice are:

Ketamine Infusion therapy– Ketamine infusion therapy involves the administration of a series of infusions for the management of psychiatric disorders like major depressive disorder, post-traumatic stress disorder, and acute suicidality.  Working very quickly — in many, often within hours — to ease symptoms.

Bioidentical hormone replacement therapy - Bioidentical hormone replacement therapy (BHRT) uses hormones that are chemically identical to the hormones naturally produced in the human body. Derived from plant sources and formulated to match the molecular structure of hormones produced by the body. BHRT is used to treat symptoms of hormonal imbalances, in both men and women.

NeuroStar® TMS – NeuroStar® TMS delivers our advanced and unique form of TMS (transcranial magnetic stimulation), a non-invasive therapy that uses targeted magnetic pulses to stimulate areas of the brain that are underactive in people suffering from depression.

Opioid Replacement Therapy - Opioid replacement therapy (ORT) is an effective treatment for addiction to opioid drugs such as heroin, oxycodone, hydromorphone (Dilaudid), fentanyl and Percocet. The therapy involves taking the opioid agonists buprenorphine (Suboxone). This medication works to prevent withdrawal and reduce cravings for opioid drugs.

Invega Sustena – a once-monthly injection treatment approved by the FDA for bipolar 1 disorder maintenance. This eliminates the need for daily oral medications in appropriate patients.Allergy Immunotherapy -

Allergen immunotherapy, also known as allergy shots, is a long-term treatment that decreases symptoms for many people with allergies often leading to lasting relief of allergy symptoms even after treatment is stopped. This makes it a cost-effective, beneficial treatment approach for many people.

Please call 904.877.1100 if you are interested in any of our services or would like to schedule an appointment.  Visit us at to learn more!