Comparing ADHD Treatments: Vyvanse vs. Adzenys

Headshot of Charles Maddix APRN, MSN, PMHNP-BC
Charles Maddix, APRN, MSN, PMHNP-BC
calendar icon
January 26, 2023

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that affects millions of individuals, both children and adults. While there is no cure for ADHD, there are several effective treatments available, including medication. Two of the most commonly prescribed medications for ADHD are Vyvanse and Adzenys. In this blog post, we will compare Vyvanse and Adzenys to help you better understand these treatments and determine which may be right for you.



Vyvanse is a stimulant medication that is used to treat ADHD and binge eating disorder. It works by increasing levels of certain neurotransmitters in the brain, including dopamine and norepinephrine, which can help improve focus, attention, and overall cognitive function. Vyvanse is a pro drug, which means it is inactive until it is metabolized by the body, resulting in a slower and longer-lasting release of medication.



Adzenys is a newer medication for ADHD that is formulated as a rapidly disintegrating tablet (ODT). This means it can be taken without water and dissolves quickly in the mouth. Like Vyvanse, Adzenys is a stimulant medication that works by increasing levels of certain neurotransmitters in the brain. Adzenys is unique in that it is formulated as an extended-release ODT, allowing for once-daily dosing and improved medication adherence.


Efficacy and Safety

Both Vyvanse and Adzenys have been shown to be effective intreating ADHD symptoms, including inattention, hyperactivity, and impulsiveness. In clinical trials, both medications were shown to improve overall ADHD symptoms and were well tolerated, with the most common side effects being decreased appetite and trouble sleeping.


Dosing and Administration

Vyvanse is available in capsule form and is taken once daily in the morning. Adzenys is available as an ODT and is taken once daily, either in the morning or afternoon, depending on the patient's individual needs and dosing schedule.


Side Effects

Both Vyvanse and Adzenys can cause side effects, although the frequency and severity can vary among individuals. Some of the most common side effects associated with both medications include:

  • Decreased appetite and weight loss
  • Trouble sleeping (insomnia)
  • Nausea or stomach pain
  • Headache
  • Anxiety or nervousness
  • Increased heart rate and blood pressure

 Other possible side effects of Vyvanse may include:

  • Irritability
  • Mood swings
  • Tics (uncontrolled muscle movements)
  • Dizziness
  • Decreased interest in sexual activity

 Possible side effects of Adzenys may include:

  • Dry mouth
  • Constipation
  • Diarrhea
  • Changes in taste
  • Vomiting

It's important to note that these lists are not exhaustive and other side effects may occur. Additionally, the severity of side effects can vary from person to person and may also depend on the dose and duration of treatment. If you are taking Vyvanse or Adzenys and experience any side effects, it's important to talk to your provider to determine the best course of action.


In conclusion, both Vyvanse and Adzenys are effective medications for treating ADHD. Both medications work by increasing levels of certain neurotransmitters in the brain, but Adzenys offers the added benefits of once-daily dosing and improved medication adherence due to its rapidly disintegrating tablet formulation. The best medication for you will depend on your individual needs and preferences, if you suffer with ADHD call us at 904.877.1100 and schedule an appointment to determine the right treatment option for you.

Charles Maddix is the Owner & CEO of The Practice.  A private practice focused on the well-being of the individual as a whole, mind and body.

Among the unique modalities offered by The Practice are:

Ketamine Infusion therapy– Ketamine infusion therapy involves the administration of a series of infusions for the management of psychiatric disorders like major depressive disorder, post-traumatic stress disorder, and acute suicidality.  Working very quickly — in many, often within hours — to ease symptoms.

Bioidentical hormone replacement therapy - Bioidentical hormone replacement therapy (BHRT) uses hormones that are chemically identical to the hormones naturally produced in the human body. Derived from plant sources and formulated to match the molecular structure of hormones produced by the body. BHRT is used to treat symptoms of hormonal imbalances, in both men and women.

NeuroStar® TMS – NeuroStar® TMS delivers our advanced and unique form of TMS (transcranial magnetic stimulation), a non-invasive therapy that uses targeted magnetic pulses to stimulate areas of the brain that are underactive in people suffering from depression.

Opioid Replacement Therapy - Opioid replacement therapy (ORT) is an effective treatment for addiction to opioid drugs such as heroin, oxycodone, hydromorphone (Dilaudid), fentanyl and Percocet. The therapy involves taking the opioid agonists buprenorphine (Suboxone). This medication works to prevent withdrawal and reduce cravings for opioid drugs.

Invega Sustena – a once-monthly injection treatment approved by the FDA for bipolar 1 disorder maintenance. This eliminates the need for daily oral medications in appropriate patients.Allergy Immunotherapy -

Allergen immunotherapy, also known as allergy shots, is a long-term treatment that decreases symptoms for many people with allergies often leading to lasting relief of allergy symptoms even after treatment is stopped. This makes it a cost-effective, beneficial treatment approach for many people.

Please call 904.877.1100 if you are interested in any of our services or would like to schedule an appointment.  Visit us at to learn more!