Comparing ADHD Treatments: Vyvanse vs. Adzenys

Charles Maddix, ARNP, MSN, PMHNP-BC

Jan 26, 2023

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that affects millions of individuals, both children and adults. While there is no cure for ADHD, there are several effective treatments available, including medication. Two of the most commonly prescribed medications for ADHD are Vyvanse and Adzenys. In this blog post, we will compare Vyvanse and Adzenys to help you better understand these treatments and determine which may be right for you.


Vyvanse is a stimulant medication that is used to treat ADHD and binge eating disorder. It works by increasing levels of certain neurotransmitters in the brain, including dopamine and norepinephrine, which can help improve focus, attention, and overall cognitive function. Vyvanse is a pro drug, which means it is inactive until it is metabolized by the body, resulting in a slower and longer-lasting release of medication.


Adzenys is a newer medication for ADHD that is formulated as a rapidly disintegrating tablet (ODT). This means it can be taken without water and dissolves quickly in the mouth. Like Vyvanse, Adzenys is a stimulant medication that works by increasing levels of certain neurotransmitters in the brain. Adzenys is unique in that it is formulated as an extended-release ODT, allowing for once-daily dosing and improved medication adherence.

Efficacy and Safety

Both Vyvanse and Adzenys have been shown to be effective intreating ADHD symptoms, including inattention, hyperactivity, and impulsiveness. In clinical trials, both medications were shown to improve overall ADHD symptoms and were well tolerated, with the most common side effects being decreased appetite and trouble sleeping.

Dosing and Administration

Vyvanse is available in capsule form and is taken once daily in the morning. Adzenys is available as an ODT and is taken once daily, either in the morning or afternoon, depending on the patient's individual needs and dosing schedule.

Side Effects

Both Vyvanse and Adzenys can cause side effects, although the frequency and severity can vary among individuals. Some of the most common side effects associated with both medications include:

  • Decreased appetite and weight loss

  • Trouble sleeping (insomnia)

  • Nausea or stomach pain

  • Headache

  • Anxiety or nervousness

  • Increased heart rate and blood pressure

 Other possible side effects of Vyvanse may include:

  • Irritability

  • Mood swings

  • Tics (uncontrolled muscle movements)

  • Dizziness

  • Decreased interest in sexual activity

 Possible side effects of Adzenys may include:

  • Dry mouth

  • Constipation

  • Diarrhea

  • Changes in taste

  • Vomiting

It's important to note that these lists are not exhaustive and other side effects may occur. Additionally, the severity of side effects can vary from person to person and may also depend on the dose and duration of treatment. If you are taking Vyvanse or Adzenys and experience any side effects, it's important to talk to your provider to determine the best course of action. 

In conclusion, both Vyvanse and Adzenys are effective medications for treating ADHD. Both medications work by increasing levels of certain neurotransmitters in the brain, but Adzenys offers the added benefits of once-daily dosing and improved medication adherence due to its rapidly disintegrating tablet formulation. The best medication for you will depend on your individual needs and preferences, if you suffer with ADHD call us at (904) 877-1100 and schedule an appointment to determine the right treatment option for you.